Unknown

Dataset Information

0

Down-regulated in OA cartilage, SFMBT2 contributes to NF-?B-mediated ECM degradation.

ABSTRACT: The interplay between anabolic and catabolic factors regulates cartilage matrix homoeostasis. In OA, this balance is disrupted which results in cartilage degradation involving a plethora of inflammatory factors. Here, we identify a novel gene "Scm-like with four MBT domains protein 2" (SFMBT2) negatively regulated in OA cartilage. Articular cartilage from human OA patients undergoing knee arthroplasty surgery exhibited significantly decreased levels of SFMBT2 compared to the normal controls. Down-regulation of SFMBT2 by specific siRNA disturbed the metabolic homoeostasis and led to decreased expression of anabolic genes (SOX9, COL2A1) while increasing the expression of catabolic genes (MMP13 and ADAMTS4), in human chondrocytes. Finally, we revealed that SFMBT2 intervention by siRNA contributed to the catabolic phenotype of human chondrocytes mediated by NF-kB pathway.

SUBMITTER: Hussain S 

PROVIDER: S-EPMC6201222 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Down-regulated in OA cartilage, SFMBT2 contributes to NF-κB-mediated ECM degradation.

Hussain Safdar S   Sun Mengyao M   Min Zixin Z   Guo Yuanxu Y   Xu Jing J   Mushtaq Nosheen N   Heng Lisong L   Huang Huang H   Zhao Yitong Y   Yuan Ying Y   Hussain Nazim N   Zhang Fujun F   Han Yan Y   Xu Peng P   Sun Jian J   Lu Shemin S   Lu Shemin S  

Journal of cellular and molecular medicine 20180822 11

The interplay between anabolic and catabolic factors regulates cartilage matrix homoeostasis. In OA, this balance is disrupted which results in cartilage degradation involving a plethora of inflammatory factors. Here, we identify a novel gene "Scm-like with four MBT domains protein 2" (SFMBT2) negatively regulated in OA cartilage. Articular cartilage from human OA patients undergoing knee arthroplasty surgery exhibited significantly decreased levels of SFMBT2 compared to the normal controls. Dow  ...[more]

Similar Datasets

Unknown PRMT5 inhibition attenuates cartilage degradation by reducing MAPK and NF-κB signaling.
| S-EPMC7650297 | biostudies-literature
Unknown CircSFMBT2-OA alleviates chondrocyte apoptosis and extracellular matrix degradation through repressing NF-κB/NLRP3 inflammasome activation.
| S-EPMC10333456 | biostudies-literature
Unknown NF-κB-mediated degradation of the coactivator RIP140 regulates inflammatory responses and contributes to endotoxin tolerance.
| S-EPMC3309172 | biostudies-literature
Unknown NF-κB-regulated, proinflammatory miRNAs in Alzheimer's disease.
| S-EPMC3580456 | biostudies-literature
Unknown Degradation of p47 by autophagy contributes to CADM1 overexpression in ATLL cells through the activation of NF-κB.
| S-EPMC6400899 | biostudies-literature
Unknown miR-3928v is induced by HBx via NF-κB/EGR1 and contributes to hepatocellular carcinoma malignancy by down-regulating VDAC3.
| S-EPMC5789631 | biostudies-literature
Unknown Disabled-1 is down-regulated in clinical breast cancer and regulates cell apoptosis through NF-κB/Bcl-2/caspase-9.
| S-EPMC6349202 | biostudies-literature
Unknown Ononin ameliorates inflammation and cartilage degradation in rat chondrocytes with IL-1β-induced osteoarthritis by downregulating the MAPK and NF-κB pathways.
| S-EPMC8793192 | biostudies-literature
Unknown Down-regulated TAB1 suppresses the replication of Coxsackievirus B5 via activating the NF-κB pathways through interaction with viral 3D polymerase.
| S-EPMC10712077 | biostudies-literature
Unknown Identification of a NF-κB cardioprotective gene program: NF-κB regulation of Hsp70.1 contributes to cardioprotection after permanent coronary occlusion.
| S-EPMC3569977 | biostudies-literature