Ontology highlight
ABSTRACT:
SUBMITTER: Deng Y
PROVIDER: S-EPMC6212432 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Deng Yujie Y Lu Jinqiu J Li Wenling W Wu Ailing A Zhang Xu X Tong Wenxue W Ho Kiwai Kevin KK Qin Ling L Song Hai H Mak Kinglun Kingston KK
Nature communications 20181101 1
Osteoarthritis is one of the leading causes of pain and disability in the aged population due to articular cartilage damage. This warrants investigation of signaling mechanisms that could protect cartilage from degeneration and degradation. Here we show in a murine model of experimental osteoarthritis that YAP activation by transgenic overexpression or by deletion of its upstream inhibitory kinases Mst1/2 preserves articular cartilage integrity, whereas deletion of YAP in chondrocytes promotes c ...[more]