LINC01287 regulates tumorigenesis and invasion via miR-298/MYB in hepatocellular carcinoma.
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ABSTRACT:
SUBMITTER: Mo Y
PROVIDER: S-EPMC6201358 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
LINC01287 regulates tumorigenesis and invasion via miR-298/MYB in hepatocellular carcinoma.
Mo Yichao Y He Longguang L Lai Zeru Z Wan Zhiheng Z Chen Qinshou Q Pan Sibo S Li Liangfu L Li Dasheng D Huang Junwei J Xue Fan F Che Siyao S
Journal of cellular and molecular medicine 20180822 11
Recently, it was reported that long non-coding RNAs (lncRNAs) participated in promoting hepatocellular carcinoma (HCC) initiation and progression. Herein, we reported that the expression level of LINC01287 was elevated in HCC cell lines and tissues. LINC01287 down-regulation inhibited HCC cells growth and invasion both in vitro and in vivo. LINC01287 exerted as a ceRNA and negatively regulated miR-298 expression. MYB was identified as a downstream target of miR-298. The miR-298/MYB axis mediated ...[more]
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