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MiR-150 Regulates Memory CD8 T Cell Differentiation via c-Myb.


ABSTRACT: MicroRNAs play an important role in T cell responses. However, how microRNAs regulate CD8 T cell memory remains poorly defined. Here, we found that miR-150 negatively regulates CD8 T cell memory in vivo. Genetic deletion of miR-150 disrupted the balance between memory precursor and terminal effector CD8 T cells following acute viral infection. Moreover, miR-150-deficient memory CD8 T cells were more protective upon rechallenge. A key circuit whereby miR-150 repressed memory CD8 T cell development through the transcription factor c-Myb was identified. Without miR-150, c-Myb was upregulated and anti-apoptotic targets of c-Myb, such as Bcl-2 and Bcl-xL, were also increased, suggesting a miR-150-c-Myb survival circuit during memory CD8 T cell development. Indeed, overexpression of non-repressible c-Myb rescued the memory CD8 T cell defects caused by overexpression of miR-150. Overall, these results identify a key role for miR-150 in memory CD8 T cells through a c-Myb-controlled enhanced survival circuit.

SUBMITTER: Chen Z 

PROVIDER: S-EPMC5611819 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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miR-150 Regulates Memory CD8 T Cell Differentiation via c-Myb.

Chen Zeyu Z   Stelekati Erietta E   Kurachi Makoto M   Yu Sixiang S   Cai Zhangying Z   Manne Sasikanth S   Khan Omar O   Yang Xiaolu X   Wherry E John EJ  

Cell reports 20170901 11


MicroRNAs play an important role in T cell responses. However, how microRNAs regulate CD8 T cell memory remains poorly defined. Here, we found that miR-150 negatively regulates CD8 T cell memory in vivo. Genetic deletion of miR-150 disrupted the balance between memory precursor and terminal effector CD8 T cells following acute viral infection. Moreover, miR-150-deficient memory CD8 T cells were more protective upon rechallenge. A key circuit whereby miR-150 repressed memory CD8 T cell developmen  ...[more]

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