Ontology highlight
ABSTRACT:
SUBMITTER: Chen Z
PROVIDER: S-EPMC5611819 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Chen Zeyu Z Stelekati Erietta E Kurachi Makoto M Yu Sixiang S Cai Zhangying Z Manne Sasikanth S Khan Omar O Yang Xiaolu X Wherry E John EJ
Cell reports 20170901 11
MicroRNAs play an important role in T cell responses. However, how microRNAs regulate CD8 T cell memory remains poorly defined. Here, we found that miR-150 negatively regulates CD8 T cell memory in vivo. Genetic deletion of miR-150 disrupted the balance between memory precursor and terminal effector CD8 T cells following acute viral infection. Moreover, miR-150-deficient memory CD8 T cells were more protective upon rechallenge. A key circuit whereby miR-150 repressed memory CD8 T cell developmen ...[more]