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A synthetic model of the nonheme iron-superoxo intermediate of cysteine dioxygenase.

ABSTRACT: A nonheme Fe(ii) complex (1) that models substrate-bound cysteine dioxygenase (CDO) reacts with O2 at -80 °C to yield a purple intermediate (2). Analysis with spectroscopic and computational methods determined that 2 features a thiolate-ligated Fe(iii) center bound to a superoxide radical, mimicking the putative structure of a key CDO intermediate.

SUBMITTER: Fischer AA 

PROVIDER: S-EPMC6201693 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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A synthetic model of the nonheme iron-superoxo intermediate of cysteine dioxygenase.

Fischer Anne A AA   Lindeman Sergey V SV   Fiedler Adam T AT  

Chemical communications (Cambridge, England) 20180924 80

A nonheme Fe(ii) complex (1) that models substrate-bound cysteine dioxygenase (CDO) reacts with O<sub>2</sub> at -80 °C to yield a purple intermediate (2). Analysis with spectroscopic and computational methods determined that 2 features a thiolate-ligated Fe(iii) center bound to a superoxide radical, mimicking the putative structure of a key CDO intermediate. ...[more]

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