Ontology highlight
ABSTRACT:
SUBMITTER: Hansen MMK
PROVIDER: S-EPMC6202163 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Hansen Maike M K MMK Desai Ravi V RV Simpson Michael L ML Weinberger Leor S LS
Cell systems 20180919 4
Transcription is an episodic process characterized by probabilistic bursts, but how the transcriptional noise from these bursts is modulated by cellular physiology remains unclear. Using simulations and single-molecule RNA counting, we examined how cellular processes influence cell-to-cell variability (noise). The results show that RNA noise is higher in the cytoplasm than the nucleus in ∼85% of genes across diverse promoters, genomic loci, and cell types (human and mouse). Measurements show fur ...[more]