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Reducing impulsive choice: V. The role of timing in delay-exposure training.

ABSTRACT: Impulsive decision-making is common in addiction-related disorders, with some research suggesting it plays a causal role in their development. Therefore, reducing impulsive decision-making may prevent or reduce addiction-related behaviors. Recent research shows that prolonged experience with response-contingent delayed reward (delay exposure [DE] training) reduces impulsive choice in rats, but it is unclear what behavioral mechanisms underlie this effect. The present study evaluated whether improvements in interval timing mediate the effects of DE training on impulsive choice. Thirty-nine Long-Evans rats were randomly assigned to groups completing DE, immediacy-, or no-exposure training, followed by impulsive-choice and timing tasks (temporal bisection). Despite replicating the DE effect on impulsive choice, timing accuracy and precision were unaffected by DE training and unrelated to impulsive choice. The present findings did not replicate previous reports that timing precision and impulsive choice are related, which may be due to between-laboratory differences in impulsive choice tasks. Continued research to identify candidate behavioral mechanisms of DE training may assist in improving training efficacy and facilitating translational efforts.

SUBMITTER: Rung JM

PROVIDER: S-EPMC6202267 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Reducing impulsive choice: V. The role of timing in delay-exposure training.

Rung Jillian M JM Buhusi Catalin V CV Madden Gregory J GJ

Behavioural processes 20180425

Impulsive decision-making is common in addiction-related disorders, with some research suggesting it plays a causal role in their development. Therefore, reducing impulsive decision-making may prevent or reduce addiction-related behaviors. Recent research shows that prolonged experience with response-contingent delayed reward (delay exposure [DE] training) reduces impulsive choice in rats, but it is unclear what behavioral mechanisms underlie this effect. The present study evaluated whether impr ...[more]

PMID: 29704551

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Project description:A prior study demonstrated increased overall response rates on a fixed interval (FI) schedule of reward in female offspring that had been subjected to maternal lead (Pb) exposure, prenatal stress (PS) and offspring stress challenge relative to control, prenatal stress alone, lead alone and lead+prenatal stress alone (Virgolini et al., 2008). Response rates on FI schedules have been shown to directly relate to measures of self-control (impulsivity) in children and in infants (Darcheville et al., 1992, 1993). The current study sought to determine whether enhanced effects of Pb±PS would therefore be seen in a more direct measure of impulsive choice behavior, i.e., a delay discounting paradigm. Offspring of dams exposed to 0 or 50ppm Pb acetate from 2 to 3 months prior to breeding through lactation, with or without immobilization restraint stress (PS) on gestational days 16 and 17, were trained on a delay discounting paradigm that offered a choice between a large reward (three 45mg food pellets) after a long delay or a small reward (one 45mg food pellet) after a short delay, with the long delay value increased from 0s to 30s across sessions. Alterations in extinction of this performance, and its subsequent re-acquisition after reinforcement delivery was reinstated were also examined. Brains of littermates of behaviorally-trained offspring were utilized to examine corresponding changes in monoamines and in levels of brain derived neurotrophic factor (BDNF), the serotonin transporter (SERT) and the N-methyl-d-aspartate receptor (NMDAR) 2A in brain regions associated with impulsive choice behavior. Results showed that Pb±PS-induced changes in delay discounting occurred almost exclusively in males. In addition to increasing percent long delay responding at the indifference point (i.e., reduced impulsive choice behavior), Pb±PS slowed acquisition of delayed discounting performance, and increased numbers of both failures to and latencies to initiate trials. Overall, the profile of these alterations were more consistent with impaired learning/behavioral flexibility and/or with enhanced sensitivity to the downshift in reward opportunities imposed by the transition from delay discounting training conditions to delay discounting choice response contingencies. Consistent with these behavioral changes, Pb±PS treated males also showed reductions in brain serotonin function in all mesocorticolimbic regions, broad monoamine changes in nucleus accumbens, and reductions in both BDNF and NMDAR 2A levels and increases in SERT in frontal cortex, i.e., in regions and neurotransmitter systems known to mediate learning/behavioral flexibility, and which were of greater impact in males. The current findings do not fully support a generality of the enhancement of Pb effects by PS, as previously seen with FI performance in females (Virgolini et al., 2008), and suggest a dissociation of the behaviors controlled by FI and delay discounting paradigms, at least in response to Pb±PS in rats. Collectively, however, the findings remain consistent with sex-dependent differences in the impacts of both Pb and PS and with the need to understand both the role of contingencies of reinforcement and underlying neurobiological effects in these sex differences.

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Reducing impulsive choice: V. The role of timing in delay-exposure training.

Publications

Reducing impulsive choice: V. The role of timing in delay-exposure training.

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