Ontology highlight
ABSTRACT:
SUBMITTER: Borger DR
PROVIDER: S-EPMC2387098 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Biochemical and biophysical research communications 20080324 2
This study was undertaken to interrogate cancer cell survival during long-term hypoxic stress. Two systems with relevance to carcinogenesis were employed: Fully transformed BJ cells and a renal carcinoma cell line (786-0). The dynamic of AMPK activity was consistent with a prosurvival role during chronic hypoxia. This was further supported by the effects of AMPK agonists and antagonists (AICAR and compound C). Expression of a dominant-negative AMPK alpha resulted in a decreased ATP level and sig ...[more]