Ontology highlight
ABSTRACT:
SUBMITTER: Pinol RA
PROVIDER: S-EPMC6203600 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Piñol Ramón A RA Zahler Sebastian H SH Li Chia C Saha Atreyi A Tan Brandon K BK Škop Vojtěch V Gavrilova Oksana O Xiao Cuiying C Krashes Michael J MJ Reitman Marc L ML
Nature neuroscience 20181022 11
Bombesin-like receptor 3 (BRS3) is an orphan G-protein-coupled receptor that regulates energy homeostasis and heart rate. We report that acute activation of Brs3-expressing neurons in the dorsomedial hypothalamus (DMH<sup>Brs3</sup>) increased body temperature (Tb), brown adipose tissue temperature, energy expenditure, heart rate, and blood pressure, with no effect on food intake or physical activity. Conversely, activation of Brs3 neurons in the paraventricular nucleus of the hypothalamus had n ...[more]