Ontology highlight
ABSTRACT:
SUBMITTER: Scheff NN
PROVIDER: S-EPMC6204375 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Scheff Nicole N NN Bhattacharya Aditi A Dowse Edward E Dang Richard X RX Dolan John C JC Wang Susanna S Kim Hyesung H Albertson Donna G DG Schmidt Brian L BL
Frontiers in integrative neuroscience 20181022
The incidence of oral cancer in the United States is increasing, especially in young people and women. Patients with oral cancer report severe functional pain. Using a patient cohort accrued through the New York University Oral Cancer Center and immune-competent mouse models, we identify a sex difference in the prevalence and severity of oral cancer pain. A neutrophil-mediated endogenous analgesic mechanism is present in male mice with oral cancer. Local naloxone treatment potentiates cancer med ...[more]