Ontology highlight
ABSTRACT:
SUBMITTER: Zhang XY
PROVIDER: S-EPMC7311172 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Zhang Xin-Yan XY Dou Yan-Nong YN Yuan Lei L Li Qing Q Zhu Yan-Jing YJ Wang Meng M Sun Yan-Gang YG
eLife 20200610
Mu-opioid receptors (MORs) are crucial for analgesia by both exogenous and endogenous opioids. However, the distinct mechanisms underlying these two types of opioid analgesia remain largely unknown. Here, we demonstrate that analgesic effects of exogenous and endogenous opioids on inflammatory pain are mediated by MORs expressed in distinct subpopulations of neurons in mice. We found that the exogenous opioid-induced analgesia of inflammatory pain is mediated by MORs in Vglut2<sup>+</sup> glutam ...[more]