Peroxisome proliferator-activated receptor γ (PPARγ) induces the gene expression of integrin α_Vβ₅ to promote macrophage M2 polarization.

ABSTRACT: Peroxisome proliferator-activated receptor γ (PPARγ) is a member of the nuclear receptor superfamily and polarizes the macrophages into an anti-inflammatory M2 state. Integrins are transmembrane receptors that drive various cellular functions, including monocyte adhesion and foam cell formation. In this study, we first reported that the expression of integrins α_V and β₅ was up-regulated by PPARγ activation in RAW264.7 cells and human peripheral blood monocytes. Luciferase reporter and ChIP assay revealed that PPARγ directly bound to the potential PPAR-responsive elements sites in the 5'-flanking regions of both murine and human integrin α_V and β₅ genes, respectively. In addition, we showed that PPARγ augmented the ligation of integrins α_V

SUBMITTER: Yao Q 

PROVIDER: S-EPMC6204912 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature