Ontology highlight
ABSTRACT:
SUBMITTER: Fries GR
PROVIDER: S-EPMC5751217 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Fries Gabriel R GR Gassen Nils C NC Rein Theo T
International journal of molecular sciences 20171205 12
Among the chaperones and co-chaperones regulating the glucocorticoid receptor (GR), FK506 binding protein (FKBP) 51 is the most intensely investigated across different disciplines. This review provides an update on the role of the different co-chaperones of Hsp70 and Hsp90 in the regulation of GR function. The development leading to the focus on FKBP51 is outlined. Further, a survey of the vast literature on the mechanism and function of FKBP51 is provided. This includes its structure and bioche ...[more]