Ontology highlight
ABSTRACT:
SUBMITTER: Cui D
PROVIDER: S-EPMC6205380 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Cui Donghong D Peng Yanmin Y Zhang Chengfang C Li Zezhi Z Su Yousong Y Qi Yadan Y Xing Mengjuan M Li Jia J Kim Grace E GE Su Kevin N KN Xu Jinjie J Wang Meiti M Ding Wenhua W Piecychna Marta M Leng Lin L Hirasawa Michiru M Jiang Kaida K Young Lawrence L Xu Yifeng Y Qi Dake D Bucala Richard R
The Journal of clinical investigation 20181008 11
Atypical antipsychotics are highly effective antischizophrenic medications but their clinical utility is limited by adverse metabolic sequelae. We investigated whether upregulation of macrophage migration inhibitory factor (MIF) underlies the insulin resistance that develops during treatment with the most commonly prescribed atypical antipsychotic, olanzapine. Olanzapine monotherapy increased BMI and circulating insulin, triglyceride, and MIF concentrations in drug-naive schizophrenic patients w ...[more]