Ontology highlight
ABSTRACT:
SUBMITTER: Bi E
PROVIDER: S-EPMC6205396 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Bi Enguang E Li Rong R Bover Laura C LC Li Haiyan H Su Pan P Ma Xingzhe X Huang Chunjian C Wang Qiang Q Liu Lintao L Yang Maojie M Lin Zhijuan Z Qian Jianfei J Fu Weijun W Liu Yong-Jun YJ Yi Qing Q
The Journal of clinical investigation 20181002 11
Plasmacytoid dendritic cells (pDCs) play a key role in antiviral responses by producing type-1 IFNs. However, recent studies showed that pDCs induce immune suppression and promote tumor growth in human ovarian cancer and myeloma. The molecular mechanisms underlying pDC acquisition of these properties are unknown. Here we show that human pDCs activated by CpG inhibited growth and induced apoptosis in myeloma cells via secreted IFN-α, but direct contact with myeloma cells converted pDCs into tumor ...[more]