Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC6205397 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Zhang Yang Y Federation Alexander J AJ Kim Soomin S O'Keefe John P JP Lun Mingyue M Xiang Dongxi D Brown Jonathan D JD Steinhauser Matthew L ML Steinhauser Matthew L ML
The Journal of clinical investigation 20181002 11
Adipocyte turnover in adulthood is low, suggesting that the cellular source of new adipocytes, the adipocyte progenitor (AP), resides in a state of relative quiescence. Yet the core transcriptional regulatory circuitry (CRC) responsible for establishing a quiescent state and the physiological significance of AP quiescence are incompletely understood. Here, we integrate transcriptomic data with maps of accessible chromatin in primary APs, implicating the orphan nuclear receptor NR4A1 in AP cell-s ...[more]