Ontology highlight
ABSTRACT:
SUBMITTER: Ostrom QT
PROVIDER: S-EPMC6205887 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Ostrom Quinn T QT Kinnersley Ben B Armstrong Georgina G Rice Terri T Chen Yanwen Y Wiencke John K JK McCoy Lucie S LS Hansen Helen M HM Amos Christopher I CI Bernstein Jonine L JL Claus Elizabeth B EB Eckel-Passow Jeanette E JE Il'yasova Dora D Johansen Christoffer C Lachance Daniel H DH Lai Rose K RK Merrell Ryan T RT Olson Sara H SH Sadetzki Siegal S Schildkraut Joellen M JM Shete Sanjay S Rubin Joshua B JB Andersson Ulrika U Rajaraman Preetha P Chanock Stephen J SJ Linet Martha S MS Wang Zhaoming Z Yeager Meredith M Houlston Richard S RS Jenkins Robert B RB Wrensch Margaret R MR Melin Beatrice B Bondy Melissa L ML Barnholtz-Sloan Jill S JS
International journal of cancer 20180919 10
Glioblastoma (GBM) is the most common malignant brain tumor in the United States. Incidence of GBM increases with age, and younger age-at-diagnosis is significantly associated with improved prognosis. While the relationship between candidate GBM risk SNPs and age-at-diagnosis has been explored, genome-wide association studies (GWAS) have not previously been stratified by age. Potential age-specific genetic effects were assessed in autosomal SNPs for GBM patients using data from four previous GWA ...[more]