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Activation of Electrophile/Nucleophile Pair by a Nucleophilic and Electrophilic Solvation in a SNAr Reaction.

ABSTRACT: Nucleophilic aromatic substitution reactions of 4-chloroquinazoline toward aniline and hydrazine were used as a model system to experimentally show that a substrate bearing heteroatoms on the aromatic ring as substituent is able to establish intramolecular hydrogen bond which may be activated by the reaction media and/or the nature of the nucleophile.

SUBMITTER: Sanchez B

PROVIDER: S-EPMC6206274 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Activation of Electrophile/Nucleophile Pair by a Nucleophilic and Electrophilic Solvation in a S<sub>N</sub>Ar Reaction.

Sánchez Bruno B Calderón Cristian C Tapia Ricardo A RA Contreras Renato R Campodónico Paola R PR

Frontiers in chemistry 20181023

Nucleophilic aromatic substitution reactions of 4-chloroquinazoline toward aniline and hydrazine were used as a model system to experimentally show that a substrate bearing heteroatoms on the aromatic ring as substituent is able to establish intramolecular hydrogen bond which may be activated by the reaction media and/or the nature of the nucleophile. ...[more]

PMID: 30406087

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