Ontology highlight
ABSTRACT:
SUBMITTER: Kim S
PROVIDER: S-EPMC6206875 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Kim Sungjin S Sieburth Derek D
Cell reports 20180901 11
The mitochondrial unfolded protein response (UPR<sup>mt</sup>) is critical for maintaining mitochondrial protein homeostasis in response to mitochondrial stress, but early steps in UPR<sup>mt</sup> activation are not well understood. Here, we report a function for SPHK-1 sphingosine kinase in activating the UPR<sup>mt</sup> in C. elegans. Genetic deficiency of sphk-1 in the intestine inhibits UPR<sup>mt</sup> activation, whereas selective SPHK-1 intestinal overexpression is sufficient to activat ...[more]