Ontology highlight
ABSTRACT:
SUBMITTER: Abdelfattah N
PROVIDER: S-EPMC6208371 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Abdelfattah Nourhan N Rajamanickam Subapriya S Panneerdoss Subbarayalu S Timilsina Santosh S Yadav Pooja P Onyeagucha Benjamin C BC Garcia Michael M Vadlamudi Ratna R Chen Yidong Y Brenner Andrew A Houghton Peter P Rao Manjeet K MK
Nature communications 20181031 1
Despite improvements in overall survival, only a modest percentage of patients survives high-risk medulloblastoma. The devastating side effects of radiation and chemotherapy substantially reduce quality of life for surviving patients. Here, using genomic screens, we identified miR-584-5p as a potent therapeutic adjuvant that potentiates medulloblastoma to radiation and vincristine. MiR-584-5p inhibited medulloblastoma growth and prolonged survival of mice in pre-clinical tumor models. MiR-584-5p ...[more]