Ontology highlight
ABSTRACT:
SUBMITTER: Palomares B
PROVIDER: S-EPMC6208444 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Palomares Belen B Ruiz-Pino Francisco F Navarrete Carmen C Velasco Inmaculada I Sánchez-Garrido Miguel A MA Jimenez-Jimenez Carla C Pavicic Carolina C Vazquez Maria J MJ Appendino Giovanni G Bellido M Luz ML Calzado Marco A MA Tena-Sempere Manuel M Muñoz Eduardo E
Scientific reports 20181031 1
Over the past few years, the endocannabinoid system (ECs) has emerged as a crucial player for the regulation of food intake and energy metabolism, and its pharmacological manipulation represents a novel strategy for the management of metabolic diseases. The discovery that VCE-004.8, a dual PPARγ and CB<sub>2</sub> receptor agonist, also inhibits prolyl-hydroxylases (PHDs) and activates the HIF pathway provided a rationale to investigate its effect in in vitro models of adipogenesis and in a muri ...[more]