Human Ischaemic Cascade Studies Using SH-SY5Y Cells: a Systematic Review and Meta-Analysis.
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ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC6208743 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Human Ischaemic Cascade Studies Using SH-SY5Y Cells: a Systematic Review and Meta-Analysis.
Liu Ye Y Eaton Emma D ED Wills Taryn E TE McCann Sarah K SK Antonic Ana A Howells David W DW
Translational stroke research 20180323 6
Low translational yield for stroke may reflect the focus of discovery science on rodents rather than humans. Just how little is known about human neuronal ischaemic responses is confirmed by systematic review and meta-analysis revealing that data for the most commonly used SH-SY5Y human cells comprises only 84 papers. Oxygen-glucose deprivation, H<sub>2</sub>O<sub>2</sub>, hypoxia, glucose-deprivation and glutamate excitotoxicity yielded - 58, - 61, - 29, - 45 and - 49% injury, respectively, wit ...[more]
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