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Association Between STAT4 rs7574865 Polymorphism and Rheumatoid Arthritis: Debate Unresolved.


ABSTRACT: Background:STAT4 rs7574865 polymorphism has been evidently associated with susceptibility to Rheumatoid Arthritis (RA) in European and Eastern Asian populations, whereas studies in other countries reported otherwise. Objective:We investigated the distribution of STAT4 rs7574865 polymorphism in a group of Syrian RA patients. Methods:Eighty-one RA patients and forty healthy controls were enrolled and STAT4 rs7574865 was genotyped by direct sequencing. RA patients were stratified according to Anti-Citrullinated Protein Antibodies (ACPA) status for analysis. Results:Minor T allele frequencies were 30.4%, 16.7%, and 23.8% in ACPA-positive RA patients, ACPA-negative RA patients, and healthy controls, respectively. No significant differences in STAT4 rs7574865 allele/genotype frequencies were found between ACPA-positive RA patients, ACPA-negative RA patients, and healthy controls (P>0.05). Conclusion:STAT4 rs7574865 TT genotype showed a potential impact on ACPA positivity in Syrian RA patients. However, STAT4 rs7574865 effect on RA onset and severity is minor compared to other genetic factors such as HLA-DRB1 shared epitope alleles.

SUBMITTER: Tarakji I 

PROVIDER: S-EPMC6210524 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Association Between <i>STAT4</i> rs7574865 Polymorphism and Rheumatoid Arthritis: Debate Unresolved.

Tarakji Iman I   Habbal Wafa W   Monem Fawza F  

The open rheumatology journal 20181024


<h4>Background</h4><i>STAT4</i> rs7574865 polymorphism has been evidently associated with susceptibility to Rheumatoid Arthritis (RA) in European and Eastern Asian populations, whereas studies in other countries reported otherwise.<h4>Objective</h4>We investigated the distribution of <i>STAT4</i> rs7574865 polymorphism in a group of Syrian RA patients.<h4>Methods</h4>Eighty-one RA patients and forty healthy controls were enrolled and <i>STAT4</i> rs7574865 was genotyped by direct sequencing. RA  ...[more]

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