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Bipolar Tumor-Associated Macrophages in Ovarian Cancer as Targets for Therapy.

ABSTRACT: Ovarian cancer, a rare but fatal disease, has been a challenging area in the field of gynecological cancer. Ovarian cancer is characterized by peritoneal metastasis, which is facilitated by a cross-talk between tumor cells and other cells in the tumor microenvironment (TME). In epithelial ovarian cancer, tumor-associated macrophages (TAMs) constitute over 50% of cells in the peritoneal TME and malignant ascites, and are potential targets for therapy. Here, we review the bipolar nature of TAMs and the evolving strategies to target TAMs in ovarian cancer.

SUBMITTER: Gupta V

PROVIDER: S-EPMC6210537 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Bipolar Tumor-Associated Macrophages in Ovarian Cancer as Targets for Therapy.

Gupta Vijayalaxmi V Yull Fiona F Khabele Dineo D

Cancers 20180929 10

Ovarian cancer, a rare but fatal disease, has been a challenging area in the field of gynecological cancer. Ovarian cancer is characterized by peritoneal metastasis, which is facilitated by a cross-talk between tumor cells and other cells in the tumor microenvironment (TME). In epithelial ovarian cancer, tumor-associated macrophages (TAMs) constitute over 50% of cells in the peritoneal TME and malignant ascites, and are potential targets for therapy. Here, we review the bipolar nature of TAMs an ...[more]

PMID: 30274280

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