Unknown

Dataset Information

0

Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase.

ABSTRACT: The tumor microenvironment for epithelial ovarian cancer is complex and rich in bioactive molecules that modulate cell-cell interactions and stimulate numerous signal transduction cascades. These signals ultimately modulate all aspects of tumor behavior including progression, metastasis and therapeutic response. Many of the signaling pathways converge on the small GTPase Ras-related C3 botulinum toxin substrate (Rac)1. In addition to regulating actin cytoskeleton remodeling necessary for tumor cell adhesion, migration and invasion, Rac1 through its downstream effectors, regulates cancer cell survival, tumor angiogenesis, phenotypic plasticity, quiescence, and resistance to therapeutics. In this review we discuss evidence for Rac1 activation within the ovarian tumor microenvironment, mechanisms of Rac1 dysregulation as they apply to ovarian cancer, and the potential benefits of targeting aberrant Rac1 activity in this disease. The potential for Rac1 contribution to extraperitoneal dissemination of ovarian cancer is addressed.

SUBMITTER: Hudson LG 

PROVIDER: S-EPMC6211091 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase.

Hudson Laurie G LG   Gillette Jennifer M JM   Kang Huining H   Rivera Melanie R MR   Wandinger-Ness Angela A  

Cancers 20180927 10

The tumor microenvironment for epithelial ovarian cancer is complex and rich in bioactive molecules that modulate cell-cell interactions and stimulate numerous signal transduction cascades. These signals ultimately modulate all aspects of tumor behavior including progression, metastasis and therapeutic response. Many of the signaling pathways converge on the small GTPase Ras-related C3 botulinum toxin substrate (Rac)1. In addition to regulating actin cytoskeleton remodeling necessary for tumor c  ...[more]

Similar Datasets

Unknown Signaling within the epithelial ovarian cancer tumor microenvironment: the challenge of tumor heterogeneity.
| S-EPMC7396799 | biostudies-literature
Unknown The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment.
| S-EPMC4601362 | biostudies-other
Unknown The Endometriotic Tumor Microenvironment in Ovarian Cancer.
| S-EPMC6115869 | biostudies-other
Unknown Inhibition of Tumor Microenvironment Cytokine Signaling Sensitizes Ovarian Cancer Cells to Antiestrogen Therapy.
| S-EPMC9564160 | biostudies-literature
Unknown Gain-of-function mutant p53 activates small GTPase Rac1 through SUMOylation to promote tumor progression.
| S-EPMC5647935 | biostudies-literature
Unknown Driving Immune Responses in the Ovarian Tumor Microenvironment.
| S-EPMC7843421 | biostudies-literature
Unknown Role of tumor microenvironment in ovarian cancer pathobiology.
| S-EPMC5978268 | biostudies-literature
Unknown The Tumor Microenvironment of Clear-Cell Ovarian Cancer.
| S-EPMC9627265 | biostudies-literature
Unknown Spatial tumor immune microenvironment phenotypes in ovarian cancer.
| S-EPMC11258306 | biostudies-literature
Unknown Wnt Signaling in the Tumor Microenvironment.
| S-EPMC8477804 | biostudies-literature