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Improved Macaca fascicularis gene annotation reveals evolution of gene expression profiles in multiple tissues.

ABSTRACT:

Backgrounds

Macaca fascicularis (M. fascicularis) is a primate model organism that played important role in studying human health. It is vital to better understand the similarity and differences of gene regulation between M. fascicularis and human. Current comparative study of gene regulation between the two species are limited by low quality of gene annotation and lack of regulatory element data on M. fascicularis genome.

Results

In this study, we improved the M. fascicularis gene annotation with 57 gene expression data from multiple tissues and, more importantly, a manual curation procedure. The new annotation enabled us to map gene expression and identify gene location more accurately.

Conclusions

Comparing with human gene expression data from the same cell types, we characterized the evolution of expression patterns of homologous genes.

SUBMITTER: Tan T

PROVIDER: S-EPMC6211470 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Improved Macaca fascicularis gene annotation reveals evolution of gene expression profiles in multiple tissues.

Tan Tao T Xia Lin L Tu Kailing K Tang Jie J Yin Senlin S Dai Lunzhi L Lei Peng P Dong Biao B Hu Hongbo H Fan Yong Y Yu Yang Y Xie Dan D

BMC genomics 20181101 1

<h4>Backgrounds</h4>Macaca fascicularis (M. fascicularis) is a primate model organism that played important role in studying human health. It is vital to better understand the similarity and differences of gene regulation between M. fascicularis and human. Current comparative study of gene regulation between the two species are limited by low quality of gene annotation and lack of regulatory element data on M. fascicularis genome.<h4>Results</h4>In this study, we improved the M. fascicularis gen ...[more]

PMID: 30382841

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