Ontology highlight
ABSTRACT:
SUBMITTER: Lehrer EJ
PROVIDER: S-EPMC6213912 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Lehrer Eric J EJ McGee Heather M HM Peterson Jennifer L JL Vallow Laura L Ruiz-Garcia Henry H Zaorsky Nicholas G NG Sharma Sonam S Trifiletti Daniel M DM
International journal of molecular sciences 20181007 10
Brain metastases traditionally carried a poor prognosis with an overall survival of weeks to months in the absence of treatment. Radiation therapy modalities include whole brain radiation therapy (WBRT) and stereotactic radiosurgery (SRS). WBRT delivers a relatively low dose of radiation, has neurocognitive sequelae, and has not been investigated for its immunostimulatory effects. Furthermore, WBRT exposes the entire intracranial tumor immune microenvironment to radiation. SRS delivers a high do ...[more]