Ontology highlight
ABSTRACT:
SUBMITTER: Fletcher JT
PROVIDER: S-EPMC6214158 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Fletcher James T JT Sobczyk Jill M JM Gwazdacz Sarah C SC Blanck Aaron J AJ
Bioorganic & medicinal chemistry letters 20180910 20
A series of 1,3,4-trisubstituted-1,2,3-triazolium bromide salts were prepared by efficient two-step sequences of azide-alkyne cycloaddition and benzylic substitution. The antimicrobial activity of each triazolium salt and correlating triazole precursor was evaluated using a minimum inhibitory concentration (MIC) assay. MIC activities as low as 1 µM against Gram-positive bacteria, 8 µM against Gram-negative bacteria and 4 µM against fungi were observed for salt analogs, while neutral triazoles we ...[more]