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An Efficient Synthesis of Hydroxyethylene Dipeptide Isosteres: The Core Unit of Potent HIV-1 Protease Inhibitors.

ABSTRACT: An efficient and stereocontrolled synthesis of hydroxyethylene dipeptide isosteres 1 from commercially available, optically pure D-mannose is described. This synthesis represents a practical and enantioselective entry to a range of other dipeptide isosteres, which are not limited to amino acid derived substituents.

SUBMITTER: Ghosh AK

PROVIDER: S-EPMC6214462 | biostudies-literature | 1991 Nov

REPOSITORIES: biostudies-literature

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An Efficient Synthesis of Hydroxyethylene Dipeptide Isosteres: The Core Unit of Potent HIV-1 Protease Inhibitors.

Ghosh Arun K AK McKee Sean P SP Thompson Wayne J WJ

The Journal of organic chemistry 19911101 23

An efficient and stereocontrolled synthesis of hydroxyethylene dipeptide isosteres <b>1</b> from commercially available, optically pure D-mannose is described. This synthesis represents a practical and enantioselective entry to a range of other dipeptide isosteres, which are not limited to amino acid derived substituents. ...[more]

PMID: 30393394

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