A swarm of slippery micropropellers penetrates the vitreous body of the eye.
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ABSTRACT:
SUBMITTER: Wu Z
PROVIDER: S-EPMC6214640 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
A swarm of slippery micropropellers penetrates the vitreous body of the eye.
Wu Zhiguang Z Troll Jonas J Jeong Hyeon-Ho HH Wei Qiang Q Stang Marius M Ziemssen Focke F Wang Zegao Z Dong Mingdong M Schnichels Sven S Qiu Tian T Fischer Peer P
Science advances 20181102 11
The intravitreal delivery of therapeutic agents promises major benefits in the field of ocular medicine. Traditional delivery methods rely on the random, passive diffusion of molecules, which do not allow for the rapid delivery of a concentrated cargo to a defined region at the posterior pole of the eye. The use of particles promises targeted delivery but faces the challenge that most tissues including the vitreous have a tight macromolecular matrix that acts as a barrier and prevents its penetr ...[more]
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