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MiR-137 is a tumor suppressor in endometrial cancer and is repressed by DNA hypermethylation.

ABSTRACT: Endometrial cancer is the most common gynecological cancer in the United States. We wanted to identify epigenetic aberrations involving microRNAs (miRNAs), whose genes become hypermethylated in endometrial primary tumors. By integrating known miRNA sequences from the miRNA database (miRBase) with DNA methylation data from methyl-CpG-capture sequencing, we identified 111 differentially methylated regions (DMRs) associated with CpG islands (CGIs) and miRNAs. Among them, 22 DMRs related to 29 miRNAs and within 8?kb of CGIs were hypermethylated in endometrial tumors but not in normal endometrium. miR-137 was further validated in additional endometrial primary tumors. Hypermethylation of miR-137 was found in both endometrioid and serous endometrial cancer (P?

SUBMITTER: Zhang W

PROVIDER: S-EPMC6214735 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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miR-137 is a tumor suppressor in endometrial cancer and is repressed by DNA hypermethylation.

Zhang Wei W Chen Jo-Hsin JH Shan Tianjiao T Aguilera-Barrantes Irene I Wang Li-Shu LS Huang Tim Hui-Ming TH Rader Janet S JS Sheng Xiugui X Huang Yi-Wen YW

Laboratory investigation; a journal of technical methods and pathology 20180628 11

Endometrial cancer is the most common gynecological cancer in the United States. We wanted to identify epigenetic aberrations involving microRNAs (miRNAs), whose genes become hypermethylated in endometrial primary tumors. By integrating known miRNA sequences from the miRNA database (miRBase) with DNA methylation data from methyl-CpG-capture sequencing, we identified 111 differentially methylated regions (DMRs) associated with CpG islands (CGIs) and miRNAs. Among them, 22 DMRs related to 29 miRNA ...[more]

PMID: 29955087

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Tumor-suppressor role of miR-139-5p in endometrial cancer.

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UHRF1 promotes proliferation of gastric cancer via mediating tumor suppressor gene hypermethylation.

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