Ontology highlight
ABSTRACT:
SUBMITTER: Huang YW
PROVIDER: S-EPMC4015135 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Huang Yi-Wen YW Kuo Chieh-Ti CT Chen Jo-Hsin JH Goodfellow Paul J PJ Huang Tim H-M TH Rader Janet S JS Uyar Denise S DS
Gynecologic oncology 20140214 2
<h4>Objectives</h4>Aberrant expression of SOX4 in endometrial cancer has been identified and partially was contributed to hypermethylation of miR-129-2. Other miRNAs are suspected to influence SOX 4 as well. The current study seeks to identify other hypermethylated miRNAs that regulate SOX4 in endometrial carcinomas.<h4>Methods</h4>Methylation levels of miRNA promoter regions were measured by combined bisulfite restriction analysis (COBRA) and pyrosequencing assays. Gene expression was determine ...[more]