Ontology highlight
ABSTRACT:
SUBMITTER: McFarland JM
PROVIDER: S-EPMC6214982 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Nature communications 20181102 1
The availability of multiple datasets comprising genome-scale RNAi viability screens in hundreds of diverse cancer cell lines presents new opportunities for understanding cancer vulnerabilities. Integrated analyses of these data to assess differential dependency across genes and cell lines are challenging due to confounding factors such as batch effects and variable screen quality, as well as difficulty assessing gene dependency on an absolute scale. To address these issues, we incorporated cell ...[more]