Ontology highlight
ABSTRACT:
SUBMITTER: Cheng R
PROVIDER: S-EPMC6215058 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Cheng Rong R Tang Min M Martinez Izri I Ayodele Temitope T Baez Penelope P Reyes-Dumeyer Dolly D Lantigua Rafael R Medrano Martin M Jimenez-Velazquez Ivonne I Lee Joseph H JH Beecham Gary W GW Reitz Christiane C
Alzheimer's & dementia (Amsterdam, Netherlands) 20180827
<h4>Introduction</h4>Less than 10% of early-onset Alzheimer's disease (EOAD) is explained by known mutations.<h4>Methods</h4>We conducted genetic linkage analysis of 68 well-phenotyped Caribbean Hispanic families without clear inheritance patterns or mutations in <i>APP</i>, <i>PSEN1</i>, and <i>PSEN2</i> and with two or more individuals with EOAD.<h4>Results</h4>We identified 16 (logarithm of odds > 3.6) linked regions, including eight novel loci for EOAD (2p15, 5q14.1, 11p15.1, 13q21.22, 13q33 ...[more]