Ontology highlight
ABSTRACT:
SUBMITTER: Barral S
PROVIDER: S-EPMC4690771 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Alzheimer's & dementia : the journal of the Alzheimer's Association 20151001 12
<h4>Introduction</h4>We performed linkage analyses in Caribbean Hispanic families with multiple late-onset Alzheimer's disease (LOAD) cases to identify regions that may contain disease causative variants.<h4>Methods</h4>We selected 67 LOAD families to perform genome-wide linkage scan. Analysis of the linked regions was repeated using the entire sample of 282 families. Validated chromosomal regions were analyzed using joint linkage and association.<h4>Results</h4>We identified 26 regions linked t ...[more]