Ontology highlight
ABSTRACT:
SUBMITTER: Humphry NJ
PROVIDER: S-EPMC6215416 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Humphry Nicola J NJ Wheatley Sally P SP
Biology open 20181022 10
Survivin expression is pivotal to life and death at the cellular level. For the past decade its pro-survival activity has been attributed to its essential role in cell proliferation and its ability to inhibit apoptosis. However, a growing body of evidence suggests that it may also contribute to cell viability through an as yet undefined role in autophagy. We report that survivin overexpression in osteosarcoma (U2OS) cells is associated with increased LC3-II expression, smaller autophagosomes, en ...[more]