Negative Control of RpoS Synthesis by the sRNA ReaL in Pseudomonas aeruginosa.
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ABSTRACT:
SUBMITTER: Thi Bach Nguyen H
PROVIDER: S-EPMC6215814 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Negative Control of RpoS Synthesis by the sRNA ReaL in <i>Pseudomonas aeruginosa</i>.
Thi Bach Nguyen Hue H Romero A David D Amman Fabian F Sorger-Domenigg Theresa T Tata Muralidhar M Sonnleitner Elisabeth E Bläsi Udo U
Frontiers in microbiology 20181029
<i>Pseudomonas aeruginosa</i> (Pae) is an opportunistic human pathogen, able to resist host defense mechanisms and antibiotic treatment. In Pae, the master regulator of stress responses RpoS (σ<sup>S</sup>) is involved in the regulation of quorum sensing and several virulence genes. Here, we report that the sRNA ReaL translationally silences <i>rpoS</i> mRNA, which results in a decrease of the RpoS levels. Our studies indicated that ReaL base-pairs with the Shine-Dalgarno region of <i>rpoS</i> m ...[more]
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