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Association between urinary tin concentration and diabetes in nationally representative sample of US adults.

ABSTRACT: BACKGROUND:Animal studies indicate that chronic exposure to certain tin compounds induces pancreatic islet cell apoptosis and glucose intolerance. However, little is known about the health effects of environmental tin exposure in humans. Therefore, we evaluated the association of tin exposure with diabetes in a nationally representative sample of US adults. METHODS:We used data from a nationally representative population (n?= 3371) in the National Health and Nutrition Examination Survey 2011-14. Diabetes (n?=?605) was defined as self-reported physician's diagnosis, HbA1c ?6.5%, fasting plasma glucose ?126?mg/dL, or 2-h plasma glucose ?200?mg/dL. Tin concentrations in urine samples were determined by inductively coupled plasma mass spectrometry. Logistic regression with sample weights was used to estimate the odds ratios (ORs) of diabetes and 95% confidence intervals (CIs). RESULTS:Urinary tin concentrations were higher in individuals with diabetes (weighted median 0.58??g/L) than those without diabetes (0.39??g/L). After adjustment for urinary creatinine and other diabetes risk factors, the OR of diabetes comparing the highest with lowest quartile of urinary tin concentrations was 1.6 (95% CI 1.0-2.6; Ptrend ?=?0.02). CONCLUSIONS:Environmental tin exposure was positively and significantly associated with diabetes in US adults.

SUBMITTER: Liu B

PROVIDER: S-EPMC6218306 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Association between urinary tin concentration and diabetes in nationally representative sample of US adults.

Liu Buyun B Sun Yangbo Y Lehmler Hans-Joachim HJ Bao Wei W

Journal of diabetes 20180704 12

<h4>Background</h4>Animal studies indicate that chronic exposure to certain tin compounds induces pancreatic islet cell apoptosis and glucose intolerance. However, little is known about the health effects of environmental tin exposure in humans. Therefore, we evaluated the association of tin exposure with diabetes in a nationally representative sample of US adults.<h4>Methods</h4>We used data from a nationally representative population (n = 3371) in the National Health and Nutrition Examination ...[more]

PMID: 29877038

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Project description:BackgroundLiving arrangements are critical to the survival and well-being of older people, especially in China where the filial piety culture demands adult children care for and serve their parents. The study aimed to explore the association between living arrangements and cognitive decline among older people in China.MethodsParticipants included 6,074 older adults over 60 years old (49.65% male, mean age 67.2 years [range 60-98]) from four waves (2011-2018) of the China Health and Retirement Longitudinal Study. Two to four assessments were conducted over a follow-up of an average of 5.3 years (range, 2-7). Cognitive function was assessed using an adapted Chinese version of Mini-Mental State Examination (MMSE). Living arrangements were classified as follows: living alone, living with spouse, living with adult children, living with spouse and adult children and living with others. Multilevel models were used to investigate the relationship between living arrangements and cognitive decline, as well as the gender difference.ResultsAs the main type of living arrangements of the study participants (44.91%), living with spouse was taken as the reference group. Compared to the reference group, living alone (β=-0.126, P < 0.001), living with adult children (β=-0.136, P < 0.001), living with spouse and adult children (β=-0.040, P < 0.05) and living with others (β=-0.155, P < 0.05) were all related to a faster rate of cognitive decline. Further, the association between living arrangements and cognitive decline varied by gender. Living alone (β=-0.192, P < 0.001) was associated with a faster cognitive decline only in older men. Living with spouse and adult children (β=-0.053, P < 0.05) and living with others (β=-0.179, P < 0.05) were associated with faster cognitive decline only in older women.ConclusionThis study suggests that living arrangements in older people in China were associated with cognitive decline, and these associations varied by gender. Greater attention to living arrangements might yield practical implications for preserving the cognitive function of the older population.

Dataset Information

Association between urinary tin concentration and diabetes in nationally representative sample of US adults.

Publications

Association between urinary tin concentration and diabetes in nationally representative sample of US adults.

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