Dataset Information

White blood cell count and all-cause and cause-specific mortality in the Guangzhou biobank cohort study.

ABSTRACT:

Background

Several studies have shown positive associations between higher WBC count and deaths from all-causes, CHD, stroke and cancer among occidental populations or developed countries of Asia. No study on the association of WBC count with all-cause and cause-specific mortality in Chinese populations was reported. We studied this using prospective data from a large Chinese cohort.

Methods

We used prospective data from the Guangzhou Biobank Cohort Study (GBCS), a total of 29,925 participants in present study. A Cox proportional hazards regression model was used to estimate the hazard ratios (HR) and 95% confidence interval (CI).

Results

The hazard ratios (HR) for all-cause, CHD, and respiratory disease mortality for the highest decile of WBC count (women >?8.2?×?10⁹/L; men >?8.8?×?10⁹/L) was 1.83 (95% confidence interval (CI) 1.54, 2.17), 3.02 (95% CI 1.84, 4.98) and 2.52 (95% CI 1.49, 4.27), respectively, after adjusting for multiple potential confounders. The associations were similar when deaths during the first 2 years of follow-up were excluded. After further adjusting for pulmonary function, the highest decile of WBC count was associated with 90% higher risk of respiratory disease mortality (HR 1.90, 95% CI 1.08, 3.33). No evidence for an association between higher WBC count and cancer mortality was found. Sub-type analysis showed that only granulocyte count remained significantly predictive of all-cause, CHD, and respiratory disease mortality.

Conclusions

Elevated WBC, specifically granulocyte, count was associated with all-cause, CHD and respiratory mortality in southern Chinese. Further investigation is warranted to clarify whether decreasing inflammation would attenuate WBC count associated mortality.

SUBMITTER: Wang T

PROVIDER: S-EPMC6219250 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Publications

White blood cell count and all-cause and cause-specific mortality in the Guangzhou biobank cohort study.

Wang Tao T Jiang Chao Qiang CQ Xu Lin L Zhang Wei Sen WS Zhu Feng F Jin Ya Li YL Thomas G Neil GN Cheng Kar Keung KK Lam Tai Hing TH

BMC public health 20181106 1

<h4>Background</h4>Several studies have shown positive associations between higher WBC count and deaths from all-causes, CHD, stroke and cancer among occidental populations or developed countries of Asia. No study on the association of WBC count with all-cause and cause-specific mortality in Chinese populations was reported. We studied this using prospective data from a large Chinese cohort.<h4>Methods</h4>We used prospective data from the Guangzhou Biobank Cohort Study (GBCS), a total of 29,925 ...[more]

PMID: 30400967

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Dataset Information

White blood cell count and all-cause and cause-specific mortality in the Guangzhou biobank cohort study.

Background

Methods

Results

Conclusions

Publications

White blood cell count and all-cause and cause-specific mortality in the Guangzhou biobank cohort study.

Similar Datasets

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