Ontology highlight
ABSTRACT:
SUBMITTER: Arasaki K
PROVIDER: S-EPMC6219717 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Arasaki Kohei K Kimura Hana H Tagaya Mitsuo M Roy Craig R CR
The Journal of cell biology 20181001 11
During the initial stage of infection, <i>Legionella pneumophila</i> secretes effectors that promote the fusion of endoplasmic reticulum (ER)-derived vesicles with the <i>Legionella</i>-containing vacuole (LCV). This fusion leads to a remodeling of the plasma membrane (PM)-derived LCV into a specialized ER-like compartment that supports bacterial replication. Although the effector DrrA has been shown to activate the small GTPase Rab1, it remains unclear how DrrA promotes the tethering of host ve ...[more]