Ontology highlight
ABSTRACT:
SUBMITTER: Williamson AP
PROVIDER: S-EPMC6219719 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Williamson Adam P AP Vale Ronald D RD
The Journal of cell biology 20180823 11
The engulfment of apoptotic cells is essential for tissue homeostasis and recovering from damage. Engulfment is mediated by receptors that recognize ligands exposed on apoptotic cells such as phosphatidylserine (PS). In this study, we convert <i>Drosophila melanogaster</i> S2 cells into proficient phagocytes by transfecting the Draper engulfment receptor and replacing apoptotic cells with PS-coated beads. Similar to the T cell receptor (TCR), PS-ligated Draper forms dynamic microclusters that re ...[more]