Ontology highlight
ABSTRACT:
SUBMITTER: Resende LP
PROVIDER: S-EPMC6219720 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Resende Luís Pedro LP Monteiro Augusta A Brás Rita R Lopes Tatiana T Sunkel Claudio E CE
The Journal of cell biology 20181003 11
Aneuploidy is associated with different human diseases including cancer. However, different cell types appear to respond differently to aneuploidy, either by promoting tumorigenesis or causing cell death. We set out to study the behavior of adult <i>Drosophila melanogaster</i> intestinal stem cells (ISCs) after induction of chromosome missegregation either by abrogation of the spindle assembly checkpoint or through kinetochore disruption or centrosome amplification. These conditions induce moder ...[more]