Ontology highlight
ABSTRACT:
SUBMITTER: Upadhaya S
PROVIDER: S-EPMC6219744 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Upadhaya Samik S Sawai Catherine M CM Papalexi Efthymia E Rashidfarrokhi Ali A Jang Geunhyo G Chattopadhyay Pratip P Satija Rahul R Reizis Boris B
The Journal of experimental medicine 20181005 11
Adult hematopoiesis has been studied in terms of progenitor differentiation potentials, whereas its kinetics in vivo is poorly understood. We combined inducible lineage tracing of endogenous adult hematopoietic stem cells (HSCs) with flow cytometry and single-cell RNA sequencing to characterize early steps of hematopoietic differentiation in the steady-state. Labeled cells, comprising primarily long-term HSCs and some short-term HSCs, produced megakaryocytic lineage progeny within 1 wk in a proc ...[more]