Ontology highlight
ABSTRACT:
SUBMITTER: Zasadzinska E
PROVIDER: S-EPMC6219920 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Developmental cell 20181004 3
Centromeric chromatin defines the site of kinetochore formation and ensures faithful chromosome segregation. Centromeric identity is epigenetically specified by the incorporation of CENP-A nucleosomes. DNA replication presents a challenge for inheritance of centromeric identity because nucleosomes are removed to allow for replication fork progression. Despite this challenge, CENP-A nucleosomes are stably retained through S phase. We used BioID to identify proteins transiently associated with CEN ...[more]