Ontology highlight
ABSTRACT:
SUBMITTER: Kant R
PROVIDER: S-EPMC6220041 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Kant Ravi R Pasi Shweta S Surolia Avadhesha A
Frontiers in immunology 20181031
Th17-lymphocytes are well known for their deleterious role in autoimmunity. But does the notoriety of this repertoire extend beyond autoimmunity? In the present study we employed experimental autoimmune encephalomyelitis as model system to study the role auto-reactive Th17 cells in neuropsychiatric disorders. The mice with experimental autoimmune encephalomyelitis exhibited exaggerated grooming activity. The observed behavioral anomaly resembled obsessive compulsive disorder (OCD) upon analysis ...[more]