Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer.
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ABSTRACT:
SUBMITTER: Niemeijer AN
PROVIDER: S-EPMC6220188 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer.
Niemeijer A N AN Leung D D Huisman M C MC Bahce I I Hoekstra O S OS van Dongen G A M S GAMS Boellaard R R Du S S Hayes W W Smith R R Windhorst A D AD Hendrikse N H NH Poot A A Vugts D J DJ Thunnissen E E Morin P P Lipovsek D D Donnelly D J DJ Bonacorsi S J SJ Velasquez L M LM de Gruijl T D TD Smit E F EF de Langen A J AJ
Nature communications 20181107 1
PD-L1 immunohistochemistry correlates only moderately with patient survival and response to PD-(L)1 treatment. Heterogeneity of tumor PD-L1 expression might limit the predictive value of small biopsies. Here we show that tumor PD-L1 and PD-1 expression can be quantified non-invasively using PET-CT in patients with non-small-cell lung cancer. Whole body PD-(L)1 PET-CT reveals significant tumor tracer uptake heterogeneity both between patients, as well as within patients between different tumor le ...[more]
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