Dataset Information

Transcriptome profile analysis of leg muscle tissues between slow- and fast-growing chickens.

ABSTRACT: Chicken is widely favored by consumers because of some unique features. The leg muscles occupy an important position in the market. However, the specific mechanism for regulating muscle growth speed is not clear. In this experiment, we used Jinghai yellow chickens with different body weights at 300 days as research subjects. The chickens were divided into fast- and slow-growing groups, and we collected leg muscles after slaughtering for use in RNA-seq. After comparing the two groups, 87 differentially expressed genes (DEGs) were identified (fold change ? 2 and FDR < 0.05). The fast-growing group had 42 up-regulated genes and 45 down-regulated genes among these DEGs compared to the slow-growing group. Six items were significantly enriched in the biological process: embryo development ending in birth or egg hatching, chordate embryonic development, embryonic skeletal system development, and embryo development as well as responses to ketones and the sulfur compound biosynthetic process. Two significantly enriched pathways were found in the KEGG pathway analysis (P-value < 0.05): the insulin signaling pathway and the adipocytokine signaling pathway. This study provides a theoretical basis for the molecular mechanism of chicken growth and for improving the production of Jinghai yellow chicken.

SUBMITTER: Wu P

PROVIDER: S-EPMC6221307 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Transcriptome profile analysis of leg muscle tissues between slow- and fast-growing chickens.

Wu Pengfei P Dai Guojun G Chen Fuxiang F Chen Lan L Zhang Tao T Xie Kaizhou K Wang Jinyu J Zhang Genxi G

PloS one 20181107 11

Chicken is widely favored by consumers because of some unique features. The leg muscles occupy an important position in the market. However, the specific mechanism for regulating muscle growth speed is not clear. In this experiment, we used Jinghai yellow chickens with different body weights at 300 days as research subjects. The chickens were divided into fast- and slow-growing groups, and we collected leg muscles after slaughtering for use in RNA-seq. After comparing the two groups, 87 differen ...[more]

PMID: 30403718

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Dataset Information

Transcriptome profile analysis of leg muscle tissues between slow- and fast-growing chickens.

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Transcriptome profile analysis of leg muscle tissues between slow- and fast-growing chickens.

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