Ontology highlight
ABSTRACT:
SUBMITTER: Long N
PROVIDER: S-EPMC6221358 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Long Nanbiao N Orasch Thomas T Zhang Shizhu S Gao Lu L Xu Xiaoling X Hortschansky Peter P Ye Jing J Zhang Fenli F Xu Kai K Gsaller Fabio F Straßburger Maria M Binder Ulrike U Heinekamp Thorsten T Brakhage Axel A AA Haas Hubertus H Lu Ling L
PLoS genetics 20181026 10
Both branched-chain amino acids (BCAA) and iron are essential nutrients for eukaryotic cells. Previously, the Zn2Cys6-type transcription factor Leu3/LeuB was shown to play a crucial role in regulation of BCAA biosynthesis and nitrogen metabolism in Saccharomyces cerevisiae and Aspergillus nidulans. In this study, we found that the A. fumigatus homolog LeuB is involved in regulation of not only BCAA biosynthesis and nitrogen metabolism but also iron acquisition including siderophore metabolism. L ...[more]