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A plant-based diet in overweight individuals in a 16-week randomized clinical trial: metabolic benefits of plant protein.


ABSTRACT: BACKGROUND AND OBJECTIVES:A plant-based diet is an effective strategy in the treatment of obesity. In this 16-week randomized clinical trial, we tested the effect of a plant-based diet on body composition and insulin resistance. As a part of this trial, we investigated the role of plant protein on these outcomes. SUBJECTS AND METHODS:Overweight participants (n?=?75) were randomized to follow a plant-based (n?=?38) or a control diet (n?=?37). Dual X-ray Absorptiometry assessed body composition, Homeostasis Model Assessment (HOMA-IR) assessed insulin resistance, and a linear regression model was used to test the relationship between protein intake, body composition, and insulin resistance. RESULTS:The plant-based vegan diet proved to be superior to the control diet in improving body weight, fat mass, and insulin resistance markers. Only the vegan group showed significant reductions in body weight (treatment effect -6.5 [95% CI -8.9 to -4.1] kg; Gxt, p?

SUBMITTER: Kahleova H 

PROVIDER: S-EPMC6221888 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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A plant-based diet in overweight individuals in a 16-week randomized clinical trial: metabolic benefits of plant protein.

Kahleova Hana H   Fleeman Rebecca R   Hlozkova Adela A   Holubkov Richard R   Barnard Neal D ND  

Nutrition & diabetes 20181102 1


<h4>Background and objectives</h4>A plant-based diet is an effective strategy in the treatment of obesity. In this 16-week randomized clinical trial, we tested the effect of a plant-based diet on body composition and insulin resistance. As a part of this trial, we investigated the role of plant protein on these outcomes.<h4>Subjects and methods</h4>Overweight participants (n = 75) were randomized to follow a plant-based (n = 38) or a control diet (n = 37). Dual X-ray Absorptiometry assessed body  ...[more]

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