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Collective effects of common SNPs and risk prediction in lung cancer.

ABSTRACT: Lung cancer is the leading cause of cancer deaths in both men and women in the US. While most sporadic lung cancer cases are related to environmental factors such as smoking, genetic susceptibility may also play an important role and a number of lung cancer associated single-nucleotide polymorphisms (SNPs) have been identified although many remain to be found. The collective effects of genome-wide minor alleles of common SNPs, or the minor allele content (MAC) in an individual, have been linked with quantitative variations of complex traits and diseases. Here we studied MAC in lung cancer using previously published SNPs data sets (US and Finland samples) and found higher MAC in cases relative to matched controls. A set of 5400 SNPs with MA (MAF?

SUBMITTER: Lei X

PROVIDER: S-EPMC6221896 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Collective effects of common SNPs and risk prediction in lung cancer.

Lei Xiaoyun X Yuan Dejian D Zhu Zuobin Z Huang Shi S

Heredity 20180310 6

Lung cancer is the leading cause of cancer deaths in both men and women in the US. While most sporadic lung cancer cases are related to environmental factors such as smoking, genetic susceptibility may also play an important role and a number of lung cancer associated single-nucleotide polymorphisms (SNPs) have been identified although many remain to be found. The collective effects of genome-wide minor alleles of common SNPs, or the minor allele content (MAC) in an individual, have been linked ...[more]

PMID: 29523840

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